Overview

Mediford Corporation was established on November 1, 2023, through the integration of the clinical trial business of LSI Medience Corporation and LSIM Safety Institute Corporation, which was responsible for our non-clinical business.
In our non-clinical business, we provide contract services for non-clinical safety trials, such as safety and efficacy for candidate substances for pharmaceuticals and regenerative medicine products before they proceed to clinical trials. We conduct testing at contract testing facilities that comply with the Good Laboratory Practice (GLP) Standards, a sign of quality and reliable data.
In our clinical trial business, we provide clinical trial testing services required to develop new drugs and treatments for pharmaceutical companies and drug discovery ventures. In particular, we offer bioanalysis services with advanced analysis technology and a series of processes related to testing in clinical trials as central laboratory services.
Through the integration, Mediford has combined the knowledge and technology in pharmaceutical research and development that both businesses have accumulated, strengthening its analytical technology in both the non-clinical and clinical trial fields for diversifying new treatments and expanding its services to pharmaceutical companies and analytical laboratories within and outside Japan. We will seek to enhance our partnerships with pharmaceutical companies and venture academia in the field of advanced analysis, aiming for further growth.

Strengths

• High quality and reliable trial services
  Each testing site is a GLP compliant facility and conducts high-quality and reliable trials. We also conduct animal trials and have obtained certification from the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC International). This Association is an international non-governmental organization promoting the humane treatment of animals in scientific research, and at Mediford, we are committed to world-class standards in the care and use of our animals.
• Cutting-edge analytical equipment and technology that also supports personalized medicine
  We maintain and manage a PDX library in which patient tumor tissues are transplanted into mice, allowing us to conduct cutting-edge tests such as anti-cancer drug screening tests using PDX. We also have the latest equipment such as imaging mass spectrometry.
• Providing solutions that meet customer needs
  For clinical trial testing, we design the tests required by our customers and provide optimized solutions. We also provide consulting services in the field of non-clinical trials, from planning to implementation of trial strategies, allowing us to provide custom solutions for each customer.

FY2022 Snapshot

* Combined revenues of LSIM's clinical trial business and LSIM Safety Institute

Main Customers

• Pharmaceutical companies
• Manufacturers
• Research institutions/universities
• Drug discovery venture companies

Main Products/Services

We provide research and development support services in a wide range of fields, from basic research including the discovery phase of drug development to clinical trials, by combining the reliability of tests cultivated through our clinical trials and non-clinical trials businesses with the high analytical capabilities gained from our years of experience.

• Nonclinical Contract Research Service

  Utilizing facilities that meet state-of-the-art GLP standards, we conduct a wide variety of activities from tests for pharmaceutical approval applications to exploratory studies in the early stages of research and development and consulting.

  

• Bioanalysis Service

  Development of analytical methods for drugs, such as their metabolites and biomarkers, in biological samples, validation of analytical methods, and measurement of actual samples.

  

• Central Laboratory Services

  We support a series of processes from specimen collection to bulk testing for clinical research (clinical studies) conducted at medical institutions across Japan, responding to the globalization of drug development.

  

Mediford

The non-clinical and clinical trial market in Japan is worth more than 200 billion yen, and is expected to grow by 4% annually due to increased government support for drug discovery ventures and academia, as well as an increase in international joint clinical trials.
By disease state, the focus has traditionally been on lifestyle-related diseases, but in the future there may be conditions such as dementia where the target molecules are not fully understood, and diseases such as cancer where the effects may vary between individuals even if the target is known. We expect the proportion of some diseases to increase. In drug development, due to changes in treatment methods, non-clinical and clinical trials of new drugs and treatments are expected to increase, from small molecule drugs to antibody/nucleic acid drugs and cell- or gene-related drugs.
With the launch of Mediford on November 1, 2023, we aim to achieve even greater growth by combining the knowledge and technology in pharmaceutical research and development that previously existed in our separate non-clinical and clinical trial businesses.
We will further advance our analysis technologies such as image mass spectrometry and anti-cancer drug testing using PDX models, and further strengthen the analysis technologies required for new drugs and treatments such as cell and gene therapies.
In addition, by leveraging the advanced analysis technology mentioned above, we will pursue testing for clinical trials in Japan from pharmaceutical companies in other countries, as well as tests for international joint clinical trials from global contract research organizations (CROs) with which we are already collaborating.